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Links to Medical Literature, Textbooks and  Websites

Websites for students and physicians:

Medscape:  Diabetes and Endocrinology

Medscape is perhaps the world's leading source for medical news and up-to-date information.  This section is dedicated to the control of metabolism and related illnesses.  Many other areas are available.  New users must register; this is gratis. 

Medical Biochemistry

Professor Michael W. King's extensive site for medical students.  Features a beautiful "interactive text book" highlighting most of  the elements of medical biochemistry.

 

Articles and Lectures

What do I eat; what should I eat?

A summary of a study of physician's personal diets from Medscape entitled "What Docs Eat, What They Need to Know" with evaluations of a "normal" American diet and 8 of the commonly recommended "healthy" alternatives.  Both advantages and short-comings are presented such that these can be explained to non-professionals.  Click here to go to this site. NB: You must be registered with Medscape to use this website.

 

Emerging therapeutic targets for T2DM

This "web collection" from Nature Reviews Endocrinology (February 2014) covers important recent research and literature concerning this very prevalent disease.  Some new therapeutic targets have emerged during the past decade and are discussed here.  A "must" for both practitioners and researchers.  Click here to call up this site.

AMPK, the major regulator of metabolism?

AMP-activated protein kinase (AMPK) has long been known to be a critical controller of metabolism.  It is regulated allosterically by adenine nucleotides and through phosphorylation by hormone-activated upstream kinases.  A special issue of Molecular and Cellular Endocrinology "AMPK and the endocrine control of metabolism"  was published in January 2013.  Eleven excellent review articles covering AMPK's control of insulin secretion, liver, muscle and adipose metabolism and appetite regulation in the hypothalamus can be called up here.

Management of Hyperglycemia in type 2 Diabetes, a new Position Statement from the ADA and EASD, October 2012.

There have come many new pharmacological agents and life-style suggestions for control of type 2 diabetes during the past few years.  The American Diabetes Association and the European Association for the Study of Diabetes have published a new position statement regarding these various methods of treatment.  Click here to call up that publication.

2012: American College of Physicians, "Metformin should be the initial drug of choice for treatment of type 2 diabetes".

The ACP has recently published guidelines for pharmacotherapy treatment of diabetes type 2 when changes in lifestyle are insufficient to control blood sugar levels.  After a rigorous analysis of the effects of newer agents, the organization strongly recommends metformin as the initial drug of choice.  A detailed summary of the original article can be reached by clicking here.  Note that you must have registered with Medscape to view the article.  Registration is gratis.

Updated USDA Dietary Guidelines Released  

Updated guidelines for maintaining correct body weight and good health were posted in January.  Click here for a concise summation of these.  NB:  You must have a Medscape membership to open this file.  Membership is free and quickly established.

Banting Lecture 2009: An Unfinished Journey: Molecular Pathogenesis to Prevention of Type 1A Diabetes, George S. Eisenbarth

George Eisenbarth give us essential insight into the genetically determined autoimmune initiation of type 1 diabetes.  This has been an area of confusion for me and many others.  We have long been aware of the fact that the immune response responsible for destroying beta cells is genetically determined and yet, type 1 diabetes is less connected to the genetic picture than type 2 diabetes.  This lecture goes a long way in explaining the causes of diabetes and the possibilities of a future "cure".  Click here to download this lecture.

Textbooks:

Metabolic Regulation, a Human Perspective, Keith N. Frayn;  2nd ed., 2003, Blackwell Science, Malden, MA.

Pocket Atlas of Nutrition, H. K. Biesalski and P. Grimm;  3rd ed., 2004,  Thieme New York, N. Y.

These two books are concise and, at the same time, give excellent overviews of our anatomy, physiological functions, and energy requirements throughout life. 

Frayn's book is a joy to read.  It gives an up-to-date insight into our metabolism and the factors controlling this.  The anatomy, physiology, and biochemistry of our daily live are most clearly explained with just the right degree of details.  The Pocket Atlas of Nutrition, in spite of its title, gives an unusually rich insight into our functions and combines anatomy, physiology and biochemistry in a series of detailed but clear diagrams and good texts.  Distribution of nutrients in food sources is extremely well documented as are bodily requirements from birth to old age.  Good balanced arguments for and against supplements are presented. 

Sorry, no links here.  You must go to a book shop or library to thumb through these references.